Nostalgia warning.
From oldest to newest:

Archon: The Light and the Dark: Classical, chess-like turn-based tactics plus an arcade. There's a modern remake.

Star control 2: RPG crossed with a space simulator plus an arcade spaceship vs spaceship shooter with a tactical "rock-paper-shotgun" element plus an arcade.

Cid Meier's Pirates: RPG plus seafaring simulatior plus naval tactical simulatior plus a fighting simulator plus a rhythm game. I'm serious.
Also, here's a fun fact: when I had a Sony-Erixon (RIP ) phone I had a Java version of the game, that was totally original (!) with some functions cut off, but some functions added (!!!). In a Java phone game !
OMG I am overruned by a nostalgia right now...
Screw iPhones and smartphones, they s..k ! I want my SE Java infrared-port beauty back right now !

Space Rangers 1&2: RPG with economical elements plus space turn-based 2-d tactics plus a large-scale strategy where you are only a single unit is a "core" of the game, and are necessary to advance to a final goal. (If you are playing on "easy", those aren't even necessary to win - your bot comrades, who are playing essentially the same game, will do it on their own.) Optimal are: arcade fights in hyperspace, text quests on planets (OFTEN WITH EXTRA FULL-SCALE GAMES WITHIN THEM !!!), and, in Space Rangers 2, RTS robot wars.

You probably haven't ever heard of Space Rangers. They are awesome. Go play them.

Spore: Arcade plus a "walker" plus two different RTS games, plus a space zen sandbox thing, plus, with addon, a game-designer simulatior and all genres within a capacity of said simulatior. I must admit that without addon more a piece of art then an actual game.





Which ones do you know about ?
Is there a single bad multi-genre game ?

You're only naming the good ones!! But yeah Pirates and Archon were the absolute best

Don't like, the absolute vast majority of games fall into several genres, because there are genres for most things? Just by taking the beginning of the first sentence from wikipedia, you get:

There's 3 already.

"Action-adventure" is a single genre.
"Survival" isn't even distinct enough to be called "sub-genre". It's merely a style, IMHO.
Majority of games are of one genre. For example, "RPG-elements" aren't a genre, it's just a mechanic, and plot isn't a characteristic feature unless it's a thing in a CLOSE focus, and I just proved (or "proved") that Diablo&Co are real-time tactics games, rather then an RPG. And Civ5 isn't a wargame + economical strategy, it's a sinlgle-genre 4X strategy.

I'd say a "multi-genre" game should have at least two distinct (!!!), but closely tied branches, that aren't close to each other.

Oh, I forgot about one:
Divinity: Dragon Commander. RPG plus a large-scale risk-like strategy plus an RTS with an element of aero-shooter.
Absolutely rocks. Especially RPG part.

Action-adventure is a combination of two genres. You can have non-adventure action games, like Shootmania, or non-action adventure games, like Limbo.
This all seems highly arbitrary for the sake of being correct, especially when arcade qualifies as a genre, something that only has to do with platform. Not that it seems to align with what you use it as.

Although I just noticed you put Spore in the OP as well, so I guess you have a counterexample to your assertion right there, considering it was largely one of the biggest disappointments in recent times.

See also: Digibro's beef with the term "metroidvania".