Prey Upon is simply bad in this format. The only time it comes close to working is if they have a creature dressed with
Wolfkin Bond. Or if they play another color which actually has big creatures, like the red five-drop.
I'm not impressed with the mana wolf because I want to win games before it flips, and it usually can't block my attackers and live.
Primal Druid can, at least for a few turns. And then it accelerates/fixes your mana.
A case in point: Opponent had a 3/2 in play. They put
Wolfkin Bond on it, and played
Prey Upon targeting their new 5/4 and my
Pious Evangel. I flipped the Evangel and then played Strength of Arms on it, making it a 4/6. They had to tap their critter to make mana with
Cryptolith Rite to use
Borrowed Grace to give their critters +0/+2 to avoid getting blown out. Using their tricks this way, gaining no advantage, made me win the game quite comfortably.
TL;DR: be very careful using
Prey Upon, or you just might lose the game on the spot. The safest is probably after you flip a Werewolf, if you are still alive then
Oh, and that's probably why the pros value
Make Mischief.A lot of the top players draft aggressive decks, with one-toughness creatures, and there
Make Mischief shines. So maining it at the GP is probably a metagame call.
Anyway, the format is young, and I expect it to change quite a bit in the following weeks, as the control players find combinations that work.