Right now? I've seen a lot of plots, and of course which one works depends on the assets and skills of the characters involved. Nicol Bolas can be very straightforward, because part of his thing is being the top dog of the Multiverse. Vraska needs to be a little more devious. OK, a lot more devious, that plays to her strengths. Are they going against the Gatewatch? Or Urza? That takes a different villain. Similar, heroic strategies are very different for fighting Bolas and Fighting Phyrexia.
That said, here are two speculatives.
How would I conquer the multiverse?
Subversion. Would-be tyrants lose because there exist those with the will to resist them.
Misinformation,
Propaganda,
False orders... these are the tools that spread
Disharmony and cause my foes to
Turn Against each other. Would-be heroes like the Gatewatch wouldn't even know my name -- not as a foe, not until it's too late and they face
Insurrection while all the while dancing on my
Puppet Strings. After all, it's easier to
Divert such a force than it is to stop it: keep their
suspicions directed elsewhere, seed
betrayal, foster
Hatred, hide behind the
Shadow of Doubt, and their
Tragic Arrogance will cause their
Worst fears to become reality.
In short, make my enemy's strength into my strength.
How would I save the multiverse?
Knowledge and
Unity are key. You can't fight a threat you can't understand, and you don't want to do it alone.
Solidarity makes the Multiverse stronger than any one foe; this has been proved time and time again from the
Victory of the Coalition to the success of the
Gatewatch on Zendikar. If we're going to save the multiverse, we've got to make it
Better for everyone. This is a
Collective Effort and we need to
Join Forces. As a Planeswalker this is going to be particularly hard: some situations won't want to be saved, and you can't drag them to salvation kicking and screaming, you have to win hearts and minds. Directly overpowering the opposition isn't likely to win and if it does, that kind of victory won't last, nor will it make you any better than the likes of Bolas.
In short, identify the problem and enlighten and organize those affected.